Treatment Africa, Asia and Latin America

A mother waits outside Laputuk Health Center, Uganda, for treatment for her baby.Theme: Treatment  Africa, Asia and Latin America

The objective of this group of projects is to identify at least two antimalarial drug combinations that are safe, effective and practical to use for the treatment of uncomplicated malaria in pregnancy in Africa, Asia and Latin America.

The major activities included within this group are:

Treatment Africa
A multi-centre trial to determine the safety and effectiveness of four new antimalarial drug combinations for the treatment of malaria in the second and third trimesters of pregnancy in Africa.

Treatment Asia
A multi-centre trial to compare the safety and effectiveness of two new antimalarial drug combinations compared to standard therapy for the treatment of malaria in the second and third trimesters of pregnancy in India and other countries in South East Asia.

Treatment Latin America
A multi-centre trial to compare the safety and effectiveness of two new antimalarial drug combinations compared to standard therapy for the treatment of malaria in the second and third trimesters of pregnancy in Latin America.

Before we conduct these trials, we undertake studies to investigate how these new drugs behave in the body in order to determine the optimum drug to use in the trials and the dose to be used for testing (see pharmacokinetics activity). We aim to have completed all these treatment trials by the end of May 2013.