Theme: Prevention Africa
The objectives of this group of projects are to identify at least one safe and effective alternative to sulphadoxine-pyrimethamine (SP) for intermittent preventative treatment in pregnancy (IPTp) in Africa and to identify new strategies to replace IPTp for areas with reduced/low transmission or high SP resistance.
The major activities included in this group are:
New drugs for IPTp
A multi-centre trial to evaluate the safety and effectiveness of alternative drugs to SP for IPTp in conjunction with ITNs in areas in Africa with moderate to high levels of resistance to SP. We aim to have completed this work by the end of 2012.
New studies to replace IPTp:
IST versus IPTp with SP in West Africa
A randomised, multi-centre,controlled trial to compare standard SP - IPTp regimen (three doses of SP in second and third trimester) versus scheduled intermittent screening and treatment of malaria (ISTp) at scheduled antenatal clinic visits in the second and third trimester in pregnant women protected by insecticide treated nets in four West African countries.
Prevention Malawi – ISTp versus IPTp-SP
A multi-centre trial to compare scheduled intermittent screening and treatment in pregnancy (ISTp) versus IPTp-SP in women protected by insecticide treated nets (ITNs) for the control of malaria in pregnancy in Malawi.
IPTp Effectiveness multicentre study
A multi-centre study to monitor the effectiveness of IPTp in pregnancy by determining the relationship between the level of SP resistance in the population (using molecular markers); the efficacy of SP in clearing existing malaria infections and preventing new infections (42 day in vivo follow-up study); and the ability of IPTp-SP to reduce the adverse effect of malaria at birth (delivery unit).
We aim to have completed these studies by the end of 2013